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1. Wang H, Chirshev E, Hojo N, Suzuki T, Bertucci A, Pierce M, Perry C, Wang R, Zink J, Glackin C, Ioffe Y, Unternaehrer JJ. The epithelial-mesenchymal transcription factor Snail represses transcription of the tumor suppressor miRNA let-7 in cancer. Cancers (Basel). 2021 Mar 23;13(6):1469. doi: 10.3390/cancers13061469.
2. Chirshev E, Hojo N, Bertucci A, Sanderman L, Nguyen A, Wang H, Suzuki T, Brito E, Martinez SR, Castanon C, Mirshahidi S, Vazquez M, Wat P, Oberg KC, Ioffe YJ, Unternaehrer JJ. Epithelial/mesenchymal heterogeneity of high-grade serous ovarian carcinoma samples correlates with miRNA let-7 levels and predicts tumor growth and metastasis. Mol. Onc. 2020 Jul 11. doi: 10.1002/1878-0261.12762
3. Hong L, Gonzalez R, Unternaehrer J, Ioffe Y. Germline BRCA Mutation Rates in Latina Women Presenting for Gynecologic Oncology Care. Gynecol Obstet Invest. 2020;85(3):214-221. doi: 10.1159/000506108. Epub 2020 Mar 23.
4. Chirshev E, Oberg KC, Ioffe YJ, Unternaehrer JJ. Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer. Clin Transl Med. 2019 Aug 28;8(1):24. doi: 10.1186/s40169-019-0240-y. Review.
5. Rowland LK, Campbell PS, Wooten JV, Mavingire N, McLean L, Zylstra D, Thorne G, Daly D, Boyle K, Unternaehrer J, Brantley EJ. Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death. J Cell Biochem. 2019 Apr;120(4):6004-6014. doi: 10.1002/jcb.27887. Epub 2018 Nov 18. PMID:
30450577
6. Wang H, Unternaehrer JJ. Epithelial-mesenchymal Transition and Cancer Stem Cells: At the Crossroads of Differentiation and Dedifferentiation. Dev Dyn. 2019 Jan;248(1):10-20. doi: 10.1002/dvdy.24678. Epub 2018 Nov 22. Review. PMID: 30303578
7. Cajigas-Du Ross CK, Martinez SR, Woods-Burnham L, Duran AM, Roy S, Basu A, Ramirez JA, Ortiz-Hernández GL, Ríos-Colón L, Chirshev E, Sanchez-Hernandez E, Soto U, Greco C, Boucheix C, Chen X, Unternaehrer J, Wang C, Casiano CA. RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance. Oncotarget 2018;9(54):30363-3038484
8. Hojo N,* Huisken AL,* Wang H, Chirshev E, Kim NS, Nguyen S, Campos H, Glackin CA, Ioffe YJ, Unternaehrer JJ. Snail knockdown reverses stemness and inhibits tumour growth
in ovarian cancer. Scientific Reports 2018; 8:8704. doi: 10.1038/s41598-018-27021-z
9. Shahin SA, Wang R, Simargi S, Contreras A, Parra L, Qu L, Wen W, Dellinger T, Unternaehrer J, Tamanoi F; Zink JI; Glackin CA. Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. Nanomedicine 2018;4:1381-1394. doi: 10.1016/j.nano.2018.04.008
10. Hao J, Unternaehrer J, Cui X, Cheng N, Oji Y. Regulation of Stemness in Carcinoma Cells. Stem Cells Int. 2017;2017:7681769.
11. Nicholas DA, Zhang K, Hung C, Glasgow S, Aruni AW, Unternaehrer J, Payne KJ, Langridge WHR, De Leon M. Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β. PLoS One. 2017 May 2;12(5):e0176793. doi: 10.1371/journal.pone.0176793. PMID: 28463985
12. Kim NS, Mbongue JC, Nicholas DA, Esebanmen GE, Unternaehrer JJ, Firek AF, Langridge WH. Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Non-Canonical NF-κB Pathway. PLoS One. 2016 Feb 16;11(2):e0147509. doi: 10.1371/journal.pone.0147509.
13. Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ. A nontranscriptional role for Oct4 in the regulation of mitotic entry. PNAS 2014 111 (44) 15768-15773.
14. Unternaehrer JJ, Zhao R, Kim K, Cesana M, Powers J, Ratanasirintrawoot S, Onder T, Shibue T, Weinberg R, Daley GQ. The epithelial-mesenchymal transition factor Snail paradoxically enhances reprogramming. Stem Cell Reports. 2014 November 11; 3(5): 691–698.
15. Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science. 2012 Nov 1.
16. Xu C, Fan ZP, Müller P, Fogley R, DiBiase A, Trompouki E, Unternaehrer JJ, Torregroza I, Evans T, Daley GQ, Schier AF, Young RA, Zon LI. Nanog Regulates Endoderm Formation through the mxtx2-Nodal Pathway. Dev Cell. 2012 Mar 13;22(3):625-38.
17. Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Chromatin-modifying enzymes as modulators of reprogramming. Nature. 2012 Mar 4;483(7391):598-602.
18. Kim K*, Zhao R*, Doi A*, Ng K*, Unternaehrer J, Cahan P, Hongguang H, Loh YH, Aryee MJ, Lensch MW, Li H, Collins JJ, Feinberg AP, Daley GQ. Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol. 2011 Nov 27;29(12):1117-1119.
19. Unternaehrer JJ, Daley GQ. Induced pluripotent stem cells for modelling human diseases. Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2274-85.
20. Bloom O, Unternaehrer JJ, Jiang A, Shin JS, Delamarre L, Allen P, Mellman I. Spinophilin participates in information transfer at immunological synapses. J Cell Biol. 2008 Apr 21;181(2):203-11.
21. Jiang A, Ono S, Unternaehrer J, Jiang S, Whitney A, Connolly J, Banchereau J, Mellman I. E-cadherin/b-catenin signaling defines a distinct pathway of dendritic cell maturation. Immunity. 2007 Oct;27(4):610-24.
22. Unternaehrer JJ, Chow AY, Pypaert M, Inaba K, Mellman I. The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proc Natl Acad Sci U S A. 2007. 104(1):234-9.
23. Tesar BM, Walker WE, Unternaehrer J, Joshi NS, Chandele A, Haynes L, Kaech S, Goldstein DR. Murine myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell. 2006. 5(6):473-86.
24. Zwickey HL*, Unternaehrer JJ*, and Mellman I. Presentation of self antigens on MHC class II molecules during dendritic cell maturation. Int Immunol. 2005. 18:199.
25. Yan J, Wolff MJ, Unternaehrer J, Mellman I, Mamula MJ. Targeting antigen to CD19 on B cells efficiently activates T cells. Int Immunol. 2005. 17(7):869.
26. Chow AY*, Unternaehrer JJ*, Mellman I. MHC class II. In Measuring Immunity: Basic Biology and Clinical Assessment. Edited by Michael T Lotze and Angus W Thomson. San Diego and London, Elsevier Academic Press. 2005.
27. Meyer zum Bueschenfeld C, Unternaehrer JJ, Mellman I, Bottomly K. Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells. J Immunol. 2004. 173(10):6119.
28. Balamuth F, Leitenberg D, Unternaehrer J, Mellman I, Bottomly K. Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells. Immunity 2001. 15(5):729-38.
29. Turley SJ, Inaba K, Garrett WS, Ebersold M, Unternaehrer J, Steinman RM, Mellman I. Transport of peptide-MHC class II complexes in developing dendritic cells. Science 2000. 288(5465):522-7.
30. Gatti E, Velleca MA, Biedermann BC, Ma W, Unternaehrer J, Ebersold MW, Medzhitov R, Pober JS, Mellman I. Large-scale culture and selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34+ progenitors. J Immunol. 2000. 164(7):3600-7.
* equal contribution
* equal contribution
1. Wang H, Chirshev E, Hojo N, Suzuki T, Bertucci A, Pierce M, Perry C, Wang R, Zink J, Glackin C, Ioffe Y, Unternaehrer JJ. The epithelial-mesenchymal transcription factor Snail represses transcription of the tumor suppressor miRNA let-7 in cancer. Cancers (Basel). 2021 Mar 23;13(6):1469. doi: 10.3390/cancers13061469.
2. Chirshev E, Hojo N, Bertucci A, Sanderman L, Nguyen A, Wang H, Suzuki T, Brito E, Martinez SR, Castanon C, Mirshahidi S, Vazquez M, Wat P, Oberg KC, Ioffe YJ, Unternaehrer JJ. Epithelial/mesenchymal heterogeneity of high-grade serous ovarian carcinoma samples correlates with miRNA let-7 levels and predicts tumor growth and metastasis. Mol. Onc. 2020 Jul 11. doi: 10.1002/1878-0261.12762
3. Hong L, Gonzalez R, Unternaehrer J, Ioffe Y. Germline BRCA Mutation Rates in Latina Women Presenting for Gynecologic Oncology Care. Gynecol Obstet Invest. 2020;85(3):214-221. doi: 10.1159/000506108. Epub 2020 Mar 23.
4. Chirshev E, Oberg KC, Ioffe YJ, Unternaehrer JJ. Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer. Clin Transl Med. 2019 Aug 28;8(1):24. doi: 10.1186/s40169-019-0240-y. Review.
5. Rowland LK, Campbell PS, Wooten JV, Mavingire N, McLean L, Zylstra D, Thorne G, Daly D, Boyle K, Unternaehrer J, Brantley EJ. Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death. J Cell Biochem. 2019 Apr;120(4):6004-6014. doi: 10.1002/jcb.27887. Epub 2018 Nov 18. PMID:
30450577
6. Wang H, Unternaehrer JJ. Epithelial-mesenchymal Transition and Cancer Stem Cells: At the Crossroads of Differentiation and Dedifferentiation. Dev Dyn. 2019 Jan;248(1):10-20. doi: 10.1002/dvdy.24678. Epub 2018 Nov 22. Review. PMID: 30303578
7. Cajigas-Du Ross CK, Martinez SR, Woods-Burnham L, Duran AM, Roy S, Basu A, Ramirez JA, Ortiz-Hernández GL, Ríos-Colón L, Chirshev E, Sanchez-Hernandez E, Soto U, Greco C, Boucheix C, Chen X, Unternaehrer J, Wang C, Casiano CA. RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance. Oncotarget 2018;9(54):30363-3038484
8. Hojo N,* Huisken AL,* Wang H, Chirshev E, Kim NS, Nguyen S, Campos H, Glackin CA, Ioffe YJ, Unternaehrer JJ. Snail knockdown reverses stemness and inhibits tumour growth
in ovarian cancer. Scientific Reports 2018; 8:8704. doi: 10.1038/s41598-018-27021-z
9. Shahin SA, Wang R, Simargi S, Contreras A, Parra L, Qu L, Wen W, Dellinger T, Unternaehrer J, Tamanoi F; Zink JI; Glackin CA. Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer. Nanomedicine 2018;4:1381-1394. doi: 10.1016/j.nano.2018.04.008
10. Hao J, Unternaehrer J, Cui X, Cheng N, Oji Y. Regulation of Stemness in Carcinoma Cells. Stem Cells Int. 2017;2017:7681769.
11. Nicholas DA, Zhang K, Hung C, Glasgow S, Aruni AW, Unternaehrer J, Payne KJ, Langridge WHR, De Leon M. Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β. PLoS One. 2017 May 2;12(5):e0176793. doi: 10.1371/journal.pone.0176793. PMID: 28463985
12. Kim NS, Mbongue JC, Nicholas DA, Esebanmen GE, Unternaehrer JJ, Firek AF, Langridge WH. Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Non-Canonical NF-κB Pathway. PLoS One. 2016 Feb 16;11(2):e0147509. doi: 10.1371/journal.pone.0147509.
13. Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ. A nontranscriptional role for Oct4 in the regulation of mitotic entry. PNAS 2014 111 (44) 15768-15773.
14. Unternaehrer JJ, Zhao R, Kim K, Cesana M, Powers J, Ratanasirintrawoot S, Onder T, Shibue T, Weinberg R, Daley GQ. The epithelial-mesenchymal transition factor Snail paradoxically enhances reprogramming. Stem Cell Reports. 2014 November 11; 3(5): 691–698.
15. Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science. 2012 Nov 1.
16. Xu C, Fan ZP, Müller P, Fogley R, DiBiase A, Trompouki E, Unternaehrer JJ, Torregroza I, Evans T, Daley GQ, Schier AF, Young RA, Zon LI. Nanog Regulates Endoderm Formation through the mxtx2-Nodal Pathway. Dev Cell. 2012 Mar 13;22(3):625-38.
17. Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, Cahan P, Marcarci BO, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Chromatin-modifying enzymes as modulators of reprogramming. Nature. 2012 Mar 4;483(7391):598-602.
18. Kim K*, Zhao R*, Doi A*, Ng K*, Unternaehrer J, Cahan P, Hongguang H, Loh YH, Aryee MJ, Lensch MW, Li H, Collins JJ, Feinberg AP, Daley GQ. Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol. 2011 Nov 27;29(12):1117-1119.
19. Unternaehrer JJ, Daley GQ. Induced pluripotent stem cells for modelling human diseases. Philos Trans R Soc Lond B Biol Sci. 2011 Aug 12;366(1575):2274-85.
20. Bloom O, Unternaehrer JJ, Jiang A, Shin JS, Delamarre L, Allen P, Mellman I. Spinophilin participates in information transfer at immunological synapses. J Cell Biol. 2008 Apr 21;181(2):203-11.
21. Jiang A, Ono S, Unternaehrer J, Jiang S, Whitney A, Connolly J, Banchereau J, Mellman I. E-cadherin/b-catenin signaling defines a distinct pathway of dendritic cell maturation. Immunity. 2007 Oct;27(4):610-24.
22. Unternaehrer JJ, Chow AY, Pypaert M, Inaba K, Mellman I. The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proc Natl Acad Sci U S A. 2007. 104(1):234-9.
23. Tesar BM, Walker WE, Unternaehrer J, Joshi NS, Chandele A, Haynes L, Kaech S, Goldstein DR. Murine myeloid dendritic cell-dependent toll-like receptor immunity is preserved with aging. Aging Cell. 2006. 5(6):473-86.
24. Zwickey HL*, Unternaehrer JJ*, and Mellman I. Presentation of self antigens on MHC class II molecules during dendritic cell maturation. Int Immunol. 2005. 18:199.
25. Yan J, Wolff MJ, Unternaehrer J, Mellman I, Mamula MJ. Targeting antigen to CD19 on B cells efficiently activates T cells. Int Immunol. 2005. 17(7):869.
26. Chow AY*, Unternaehrer JJ*, Mellman I. MHC class II. In Measuring Immunity: Basic Biology and Clinical Assessment. Edited by Michael T Lotze and Angus W Thomson. San Diego and London, Elsevier Academic Press. 2005.
27. Meyer zum Bueschenfeld C, Unternaehrer JJ, Mellman I, Bottomly K. Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells. J Immunol. 2004. 173(10):6119.
28. Balamuth F, Leitenberg D, Unternaehrer J, Mellman I, Bottomly K. Distinct patterns of membrane microdomain partitioning in Th1 and Th2 cells. Immunity 2001. 15(5):729-38.
29. Turley SJ, Inaba K, Garrett WS, Ebersold M, Unternaehrer J, Steinman RM, Mellman I. Transport of peptide-MHC class II complexes in developing dendritic cells. Science 2000. 288(5465):522-7.
30. Gatti E, Velleca MA, Biedermann BC, Ma W, Unternaehrer J, Ebersold MW, Medzhitov R, Pober JS, Mellman I. Large-scale culture and selective maturation of human Langerhans cells from granulocyte colony-stimulating factor-mobilized CD34+ progenitors. J Immunol. 2000. 164(7):3600-7.
* equal contribution
* equal contribution
